Aromatase inhibitors and inactivators in breast cancer
نویسندگان
چکیده
منابع مشابه
Aromatase inhibitors in breast cancer.
The development of aromatase inhibitors for breast cancer therapy is a result of successful translational research exploring the biochemical effects of different compounds in vivo. Studies assessing plasma oestrogen levels as well as in vivo aromatase inhibition have revealed a consistent difference with respect to biochemical efficacy between the third generation compounds (anastrozole, letroz...
متن کاملAromatase inhibitors in breast cancer.
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متن کاملAre Differences in the Available Aromatase Inhibitors and Inactivators Significant?
Aromatase inhibitors are endocrine agents with a different mode of action than tamoxifen against breast tumors. In postmenopausal women, estrogen concentrations are maintained primarily via aromatase, a cytochrome P-450 enzyme that acts at the final step in the estrogen synthesis pathway. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line t...
متن کاملAre differences in the available aromatase inhibitors and inactivators significant?
Aromatase inhibitors are endocrine agents with a different mode of action than tamoxifen against breast tumors. In postmenopausal women, estrogen concentrations are maintained primarily via aromatase, a cytochrome P-450 enzyme that acts at the final step in the estrogen synthesis pathway. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line t...
متن کاملAre Differences in the Available Aromatase Inhibitors and Inactivators Significant?
Aromatase inhibitors are endocrine agents with a different mode of action than tamoxifen against breast tumors. In postmenopausal women, estrogen concentrations are maintained primarily via aromatase, a cytochrome P-450 enzyme that acts at the final step in the estrogen synthesis pathway. The first clinically available aromatase inhibitor, aminoglutethimide, was introduced for the second-line t...
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ژورنال
عنوان ژورنال: BMJ
سال: 2001
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.323.7318.880